Lois receives a surprising birthday present from her father, Carter Pewterschmidt, that leads to an unfortunate accident leaving him dependent on Lois and the Griffin’s care.

Stewie invents a shrinking machine that shrinks him and Brian down to microscopic size.

Stewie is surprised when he makes friends with another boy his age, but later taken aback when he learns that Stewie wasn’t invited to his birthday party.

Brian quickly falls in love with a woman, and after receiving devastating news regarding her cancer diagnosis, he proposes marriage.

Brian’s marriage to Jess doesn’t go as planned, especially after her miraculous cancer recovery, so at Peter’s suggestion, Brian lets himself go, leading Jess to make a surprising decision.

Sam and Dean continue to worry about the condition of Jack’s soul.

Sam and Dean race to help a friend in need. Meanwhile, Mary (guest star Samantha Smith) is concerned for Jack’s wellbeing, and Castiel enlists help from Jo/Anael to track down…

Sam and Dean are baffled when they come up against a monster they have never heard of before. Jack does his best to impress a new group of friends.

Sam and Castiel follow a case to a picturesque little town in Arkansas, only to find out nothing is as idyllic as it appears to be. Dean and Jack take…

Sam and Dean look to occult lore for a solution to their latest problem, but instead of a resolution, they find much more than either of them had anticipated.

Sam and Dean enlist the help of Rowena to track down a demi god who feasts on human flesh. The challenge of keeping Michael at bay is proving to be…

Sam and Dean must figure out how to stop the bloodshed when Donatello, who, in his current condition, is inadvertently scrambling the order of future prophets. Nick comes face to…

Dean spends some bonding time with Mary and Donna. Nick finally finds the answer he has been searching for. Sam is left to make an unimaginable choice.

Michael has re-taken control of Dean as his army of monsters continues to move in on our heroes. Sam devises a plan to try and reach Dean and stop Michael…

Sam and Dean enlist the help of their pal Garth to gain inside information on what Michael may be planning. The brothers split up to each go after weapons that…

Sam and Castiel track down a Shaman, who may be able to help a friend. Nick continues to spiral down a dark path as he looks for answers surrounding the…

When Sam and Dean join forces with an unexpected ally, the outcome will alter the course of two lives. Meanwhile, Heaven faces an attack from a dark force, driving Castiel…

Sam and Charlie team up to get to the bottom of a string of random disappearances. Meanwhile, Jack believes that he has found a case and convinces Dean to partner-up…

After a hunt gone wrong leaves Maggie’s whereabouts unknown, Sam, Dean, Mary and Bobby race to find her, but what they find are their own worst nightmares.

Dean continues to struggle. Meanwhile, Sam must think fast when action figures come to life, and our heroes find themselves living in a real-life horror movie.

Still trying to solve the mystery of what happened to Dean, Sam enlists the help of Sheriff Jody Mills who may unknowingly already be on the case. Castiel continues to…

Sam finds a clue to Dean’s whereabouts, so he, Mary and Bobby set out to investigate. Castiel imparts some sage advice on Jack, who, still desperate to belong, seeks out…

Sam enlists everyone’s help in trying to track down Dean, who can literally be anywhere. Meanwhile, Castiel may be in over his head after meeting up with an unreliable source….

Maggie introduces mood rooms as an alternative approach to medicine. Alex and DeLuca butt heads over an 11-year-old patient who tries to sabotage her own surgery. Jackson and Richard deal…

Ties are strained as Andrew and Carina confront an unforgiving family history. Meanwhile, Teddy and Owen work together on a married couple who is expecting, and Amelia attends a conference…

Meredith finds herself having to side with either Alex or DeLuca during a difficult situation, but she doesn’t want to betray either of them. Meanwhile, Maggie reveals details about her…

When Jackson throws a party to celebrate Catherine’s surgery and those who worked to save her, literally nothing goes as planned. Meanwhile, Helen pays Alex and Jo a surprise visit.

Meredith breaks a hospital record; the doctors are sent scrambling in the wake of a massive overdose within the community; Jackson wants to take Maggie camping; Levi and Nico’s relationship…

Patients flood the hospital after gunfire goes off at a parade; a blast from the past throws Maggie off her game on the same day that Meredith tries to talk…

Amelia and Koracick tackle a daunting surgery on Catherine while Richard and Jackson hope for the best. Meanwhile, Richard urges Meredith to visit her father, Thatcher, before his time is…

A patient gives Meredith some clarity on her dating situation around the holidays. The strain on Bailey and Ben’s marriage comes to a head. Meanwhile, Betty drops a bomb on…

Meredith questions Link’s laid-back approach over a patient’s treatment. Maggie worries that Richard, Jackson and Catherine haven’t come to terms with Catherine’s diagnosis. Meanwhile, Deluca steps up in the O.R….

When the power goes out at Grey Sloan, the doctors are left scrambling to save their patients’ lives; Owen, Amelia and Teddy confront their complicated situation.

Catherine is in Los Angeles getting the new foundation ready and summons Meredith and Koracick to visit for a highly confidential consult. Meanwhile, one of the nurses is 28 weeks…

Seattle is hit by a huge wind storm and Grey Sloan becomes inundated with patients. Alex and Jo are stuck at home and decide to make the best of it…

Meredith has a patient whose family is celebrating Day of the Dead, making the doctors remember loved ones they have lost. Richard shares unexpected news with Meredith about her father,…

Meredith reaches out to Teddy and helps her talk through some of her personal struggles. Owen and Amelia hide out near Betty’s school after she becomes a flight risk. Meanwhile,…